by Sineva, G.S. et al.
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia
This change is paralleled by two somewhat polar effects: (i) the accumulation of the beta-catenin, which is co-localized with E-cadherin at the plasma membrane, and the cytoplasmic, tyrosine unphosphorylated beta-catenin, which is able to bind the GST (glutathione transferase)-fused cytoplasmic domain of E-cadherin; and (ii) the accumulation of the tyrosine phosphorylated beta-catenin and its nuclear translocation that is accompanied by activation of the Tcf (T-cell factor)/beta-catenin-dependent transcription of Top-Flash reporter.
Biol. Cell. 2010; 10:549-60